RSV毛细支气管炎及其后反复喘息的相关影响因素分析

目的 探讨与呼吸道合胞病毒(RSV)致毛细支气管炎(简称细支炎)及其后反复喘息发作相关的影响因素.方法 对RSV细支炎住院患儿与正常对照组儿童生活生长各因素进行比较,并随访RSV细支炎患儿两年内喘息再发的情况,以期找到与RSV细支炎及其后婴幼儿反复喘息相关的危险因素.结果 ①RSV细支炎组与正常对照组通过Logistic回归分析,筛选出非母乳喂养、被动吸烟、未补充维生素(Vii)AD为具有统计学意义的危险因素.②200例RSV细支炎患儿随访两年,失访82例,细支炎后再发喘息组71例,未再发生喘息组47例.两组通过Logistic回归分析,筛选出被动吸烟、未补充Vit AD、个人特应史、家族特应史为具有统计学意义的危险因素.两组外周血嗜酸细胞计数、RANTES因子、血总IgE水平及TH1/TH2值差异有统计学意义.结论 ①非母乳喂养、被动吸烟、未补充Vit AD为RSV细支炎的危险因素.②被动吸烟、未补充Vit AD、个人特应史、家族特应史为RSV细支炎后反复喘息的危险因素.

The correlation factor about respiratory syncytial virus bronchiolitis and post-bronchiolitis wheezing in infant

Objective To ohserve the correlation factor about early-life RSV bronchiolitis and sequential recurrent wheezing for two years.Methods Follow up the RSV bronehiolitis patients for two years in order to analyze the occurrence of wheezing post-bronchiolitis.Single and multiple logistic regression analysis were used to determined the risk factors such as individual atopy history and familial atopy history,pet feeding,breast milk,secondhand smoke for RSV bronchiolitis and subsequent wheezing.Results①Not breast feeding,exposure to cigarette smoke and the deficiency of VitA.D were the significant risk factors contributed to the RSV bronchiolitis.②Exposure to cigarette smoke,the deficiency of VitA,D,the personal history of atopy and the family history of atopy were the significant risk factors contributed to the post-bronchiolitis wheezing in children.③Those patients who eosinophilia,high serum IgE,RANTES and decreased TH1 to TH2 Ratio were more likely to have wheezing after RSV bronchiolitis.Conclusion①Not breast feeding,exposure to cigarette smoke and the deficiency of VitA,D were the significant risk factors contributed to the RSV bronchiolitis.②Exposure to cigarette smoke,the deficiency of VitA,D,the personal history of atopy and the family history of atopy were the significant risk factors contributed to the pest-bronchiolitis wheezing in children.