| HBsAg和HBcAg在慢性乙肝病毒携带者肝组织中的表达 |
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| 引用本文： | 杨丽君,於学军,圣建惠,王建.HBsAg和HBcAg在慢性乙肝病毒携带者肝组织中的表达[J].现代保健,2008(36):28-29. |
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| 作者姓名： | 杨丽君 於学军 圣建惠 王建 |
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| 作者单位： | 镇江市第三人民医院肝炎科,212003 |
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| 摘 要： | 目的观察慢性乙肝病毒携带者血清标志物与肝组织HBcAg表达的相关性。方法对80例慢性乙肝病毒携带者行快速经皮肝穿刺术取肝组织，免疫组化染色检查HBsAg，HBcAg。荧光定量PCR法检测血清HBVDNA。ELISA法检测血清HBsAg、抗-HBs、HBeAg、抗-HBe和抗-HBc。结果血清HBsAg均阳性，血清HBeAg阳性者48例、HBeAg阴性者32例，血清HBVDNA阳性者50例、HBVDNA阴性者30例。肝组织HBsAg阳性者68例、肝组织HBcAg阳性者43例。结论慢性乙肝病毒携带者肝组织HBcAg表达与血清标志物HBVDNA、HBeAg有相关性。
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| 关 键 词： | 慢性HBV携带者 HBV DNA HBcAg 肝组织 免疫组化 |
The Expression of HBsAg and HBcAg in the Liver Tissues of Persons Carded Hepatitis B virus. |
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| Institution: | YANG Li - jun , YU Xue - jun , SHENG Jian - hui , et al. (Third People＇s Hospital Hepatitis Branch of Zhenjiang in Jiangsu. Zhenjiang 212003 China.) |
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| Abstract: | Objective To analyze the relation between serum markers of hepatitis B virus （HBV）and the expression of HBcAg in liver tissue in patients infected with HBV. Methods Pereutaneous liver paraeentesis were carried out in 80 persons carrying HBV to get liver tissue. The expressions of HBsAg and HBeAg were examined with immunochemistry. Serum HBV DNA was analyzed with fluorescence - quantity PCR. Serum HBsAg, anti - HBS, HBeAg, anti - HBC were analyzed with ELISA. Results Serum HBeAg was positive in all cases, serum HBcAg was positive in 48 eases and negative in 32 cases. Serum HBV DNA was positive in 50 cases and negative in 30 cases. HBeAg was positive in 68 liver tissues and HBcAg in 43 liver tissues. Conclusion There are relations between the expression of HBsAg in liver tissue and serum HBV DNA and serum HBeAg in patients with HBV. |
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| Keywords: | Chronic HBV carrier HBVDNA HBcAg Liver organization Immunochemistry |
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