| 凋亡与肝纤维化 |
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| 引用本文： | 黄海军,盛吉芳.凋亡与肝纤维化[J].国际流行病学传染病学杂志,2006,33(2):118-120,128. |
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| 作者姓名： | 黄海军 盛吉芳 |
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| 作者单位： | 310003,杭州,浙江大学医学院附属第一医院传染病研究所,卫生部传染病重点实验室 |
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| 摘 要： | 肝细胞和肝星形细胞(hepatic stellate cell,HSC)的凋亡与肝纤维化的形成、发展和减退有关。肝细胞凋亡产生的凋亡小体被吞噬细胞吞噬,且肝细胞凋亡本身可引起或加重炎症,均导致肝纤维化发生;HCS则通过细胞凋亡来减退肝纤维化。因此,肝细胞和肝星形细胞凋亡对肝纤维化有重要作用。
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| 关 键 词： | 细胞凋亡 肝纤维化 肝细胞 肝星形细胞 |
| 收稿时间： | 2006-02-25 |
| 修稿时间： | 2006-02-25 |
Apoptosis and liver fibrosis |
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| HUANG Hai-jun,SHENG Ji-fang.Apoptosis and liver fibrosis[J].International Journal of Epidemiology and Infectious Disease,2006,33(2):118-120,128. |
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| Authors: | HUANG Hai-jun SHENG Ji-fang |
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| Abstract: | Apoptosis of hepatocyte and hepatic stellate cell is associated with the hepatic fibrosis.Both clearance of hepatocyte apoptotic bodies through phagocytosis and hepatocyte apoptosis itself may stimulate fibrogenesis.Apoptosis of acivated hepatic stellate cells may attenuates hepatic fibrosis.So,apoptosis of hepatocyte and hepatic stellate cell is critical to hepatic fibrosis. |
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| Keywords: | Apoptosis Hepatic fibrosis Liver cell Hepatic stellate cell |
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