| 反-4-甲基环己基异氰酸酯的重排合成法 |
| |
| 引用本文： | 邓勇,沈怡,严忠勤,杨宇. 反-4-甲基环己基异氰酸酯的重排合成法[J]. 中国医药工业杂志, 2005, 36(3): 138-139 |
| |
| 作者姓名： | 邓勇 沈怡 严忠勤 杨宇 |
| |
| 作者单位： | 四川大学华西药学院,四川,成都,610041 |
| |
| 摘 要： | 对甲苯甲酸经10%Pd(OH)2/C还原、碱性异构化得反-4-甲基环己甲酸,经PCl5氯代、NaN3叠氮化后经Curtius重排得反-4-甲基环己基异氰酸酯,总收率60%.
|
| 关 键 词： | 反-4-甲基环己基异氰酸酯 格列美脲 Curtius重排 中间体 合成 |
| 文章编号： | 1001-8255(2005)03-0138-02 |
Synthesis of trans-4-methylcyclohexane Isocyanate by Curtius Rearrangement |
| |
| DENG Yong,SHEN Yi,YAN Zhong-Qin,YANG Yu. Synthesis of trans-4-methylcyclohexane Isocyanate by Curtius Rearrangement[J]. , 2005, 36(3): 138-139 |
| |
| Authors: | DENG Yong SHEN Yi YAN Zhong-Qin YANG Yu |
| |
| Abstract: | trans-4-Methylcyclohexane isocyanate was synthesized from p-toluic acid by reduction with 10%Pd(OH)2/C and then isomerization in basic solution to give trans-4-methylcyclohexanecarboxylic acid, which subjected tochlorination with phosphorus pentachloride, azidation with sodium azide and then Curtius rearrangement with an overallyield of 60%. |
| |
| Keywords: | trans-4-methylcyclohexane isocyanate glimepiride Curtius rearrangement intermediate synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
