| FOXP3基因多态性与斑秃的关联研究 |
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| 引用本文： | 杨韶艳,郭洪,宋志强,刘宝珩,郭红卫,宋秋荷,郝飞,白云. FOXP3基因多态性与斑秃的关联研究[J]. 免疫学杂志, 2010, 0(4) |
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| 作者姓名： | 杨韶艳 郭洪 宋志强 刘宝珩 郭红卫 宋秋荷 郝飞 白云 |
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| 作者单位： | 第三军医大学西南医院皮肤科;第三军医大学西南医院;遗传教研室; |
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| 基金项目： | 国家自然科学基金(30671887) |
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| 摘 要： | 目的探讨FOXP3基因多态性与斑秃(alopecia areata,AA)发生发展的关系。方法选择240例斑秃患者及248例正常对照。结合HapMap网站中汉族人群资料,选取rs3761547和rs3761548共2个单核苷酸多态性(single nucleotide polymorphism,SNP)位点,采用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)的方法进行基因分型,统计学分析单核苷酸多态性。结果与正常对照比较,斑秃患者组FOXP3基因rs3761548位点的基因型分布有差异,具有统计学意义(P=0.015);而rs3761547位点的基因型分布在正常对照组与斑秃患者组之间没有差异(P=0.12)。非条件Logistic回归分析显示,rs3761548位点的CC基因型相对于AA和AC基因型来说,对斑秃的发病具有保护效应(adjusted OR:0.69;95%CI:0.48-0.98)。单倍型分析结果显示,与对照组相比较,斑秃患者单倍型GA和单倍型GC的分布存...
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| 关 键 词： | 斑秃 FOXP3基因 多态性 |
Relationship between FOXP3 gene polymorphism and alopecia areata |
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| YANG Shaoyan,GUO Hong,SONG Zhiqiang,LIU Baoheng,GUO Hongwei,SONG Qiuhe,HAO Fei,BAI Yun. Relationship between FOXP3 gene polymorphism and alopecia areata[J]. Immunological Journal, 2010, 0(4) |
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| Authors: | YANG Shaoyan GUO Hong SONG Zhiqiang LIU Baoheng GUO Hongwei SONG Qiuhe HAO Fei BAI Yun |
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| Affiliation: | YANG Shaoyan,GUO Hong,SONG Zhiqiang,LIU Baoheng,GUO Hongwei,SONG Qiuhe,HAO Fei,BAI Yun Department of Dermatology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | To investigate whether the FOXP3 gene polymorphisms was associated with the occurrence or severity of alopecia areata (AA),we recruited 240 AA patients and 248 normal controls to study.SNPs(rs3761547,rs3761548) were defined for FOXP3 gene by using the data of Han population from the Hapmap homepage.PCR-RFLP was used for the genotyping and statistics were employed for analyzing SNP.A significant difference of the three genotypes at rs3761548 site was observed between patients and controls(P=0.015).But no ass... |
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| Keywords: | Alopecia areata FOXP3 gene Polymorphism |
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