结直肠癌肝转移预后影响因素的分析

目的 探讨结直肠癌肝转移患者预后的相关影响因素.方法 回顾性分析5年间收治的71例结直肠癌肝转移患者的临床病理资料.选择患者性别、年龄、肝转移部位、肝转移时间、转移灶数目、转移灶大小、原发肿瘤分化程度、有无淋巴转移、有无肝外转移以及肝转移病灶治疗方法等10个因素,用SPSS 17.0软件进行结直肠癌肝转移单因素分析和多因素Cox回归分析,并对有意义的相关因素进行交互作用分析.结果 71例结直肠癌肝转移患者生存时间为(16.5±5.3)个月,3年生存率为12.7％.单因素分析显示肝转移部位、转移灶数目、转移灶大小、肿瘤分化程度、有无淋巴转移、有无肝外转移以及肝转移病灶治疗方法等7个因素与预后有关,它们的组间差异均具有统计学意义(x2 =11.279,9.600,8.076,17.376,19.817,24.310,32.267；P＜0.05).Cox回归模型表明原发肿瘤分化程度(RR=1.671,95％CI 1.236 ～2.345,P=0.026),淋巴转移(RR=1.658,95％ CI1.214 ～2.286,P=0.010),有无肝外转移(RR =2.586,95％ CI 1.758 ～6.326,P=0.000)以及肝转移病灶治疗方法(RR=6.846,95％CI3.624～13.032,P=0.000)与结直肠癌肝转移预后有密切关系.结论 肿瘤分化程度、有无淋巴转移、有无肝外转移以及肝转移病灶治疗方法是结直肠癌肝转移预后的独立危险因素.

Prognostic factors for colorectal cancer liver metastases

Objective To investigate the prognostic factors of patients with liver metastases from colorectal cancer. Methods The clinicopathological data of 71 patients with liver metastasis from colorectal cancer admitted to our hospital during the past 5 years were retrospectively analyzed.Ten clinical factors of the patients that included gender,age,the size,location,and number of liver metastatic tumors,time interval between primary diagnosis and detection of liver metastasis,the differentiation level of primary t...