| CD10|p63及calponin在乳腺良恶性病变鉴别诊断中的意义 |
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| 引用本文： | 白冬雨|陈云新|杨秀红.CD10|p63及calponin在乳腺良恶性病变鉴别诊断中的意义[J].中国普通外科杂志,2011,20(11):1212-1215. |
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| 作者姓名： | 白冬雨|陈云新|杨秀红 |
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| 作者单位： | 厦门大学附属第一医院病理科;北京大学人民医院病理科;华北煤炭医学院生理学教研室; |
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| 摘 要： | 目的探讨乳腺肌上皮细胞标志物CD10,p63及calponin在乳腺良、恶性上皮性病变鉴别诊断中的意义。方法应用免疫组织化学染色法检测CD10,p63及calponin在乳腺普通型增生(UDH),非典型导管上皮增生(ADH),导管原位癌(DCIS)和浸润性导管癌(IDC)中的表达,分析其在乳腺良、恶性上皮病变诊断中的意义。结果 3种标志物在UDH,ADH和DCIS组中均有不同程度的表达,且主要表达于导管周围的肌上皮。该3组间calponin的表达量无明显差异(P>0.05);p63的表达量依次为UDH组>ADH组>DCIS组(均P<0.05);CD10的表达量在UDH组与ADH组间无明显差异,但两组均明显高于DCIS组(均P<0.05)。IDC组几乎无CD10和p63的表达,肿瘤间质有少量calponin的表达,与前3组比较,差异均有统计学意义(均P<0.0 5)。结论联合应用CD1 0,p6 3及calponin标志物的检测可鉴别诊断乳腺良恶性病变,CD1 0和p6 3特异性较好,而calponin的敏感性较好,但特异性较差。
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| 关 键 词： | 乳腺肿瘤/病理学 肌上皮 CD10 p63 Calponin |
| 收稿时间： | 2011/1/18 0:00:00 |
| 修稿时间： | 2011/10/14 0:00:00 |
The value of CD10| p63 and calponin in differential diagnosis between benign and malignant breast lesions |
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| BAI Dongyu| CHEN Yunxin| YANG Xiuhong.The value of CD10| p63 and calponin in differential diagnosis between benign and malignant breast lesions [J].Chinese Journal of General Surgery,2011,20(11):1212-1215. |
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| Authors: | BAI Dongyu| CHEN Yunxin| YANG Xiuhong |
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| Institution: | BAI Dongyu1,CHEN Yunxin2,YANG Xiuhong3(1.Department of Pathology,the First Affiliated Hospital,Xiamen University,Xiamen,Fujian 361003,China,2.Department of Pathology,the Peoples Hospital,Peking University,Beijing 100044,3.Department of Physiology,North China Coal Medical College,Tangshan,Hebei 063000,China) |
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| Abstract: | Objective To investigate the value of CD10,p63 and calponin,the markers of breast myoepithelial cells,in differential diagnosis between benign and malignant epithelial lesions of the breast.Methods The expressions of CD10,p63 and calponin in usual ductal hyperplasia(UDH),atypical ductal hyperplasia(ADH),ductal carcinoma in situ(DCIS) and invasive ductal carcinoma(IDC) of the breast were detected by immunohistochemical staining,and their diagnostic roles in benign and malignant epithelial lesions of the brea... |
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| Keywords: | Breast Neoplasms/pathol Myoepithelial Cells CD10 p63 Calponin |
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