| 三阴性乳腺癌的临床病理特征分析 |
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| 引用本文： | 钱宏美|张亚男|张勇|嵇振岭. 三阴性乳腺癌的临床病理特征分析[J]. 中国普通外科杂志, 2011, 20(11): 1196-1198 |
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| 作者姓名： | 钱宏美|张亚男|张勇|嵇振岭 |
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| 作者单位： | 安徽省马鞍山市人民医院普通外科;东南大学附属中大医院普通外科; |
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| 摘 要： | 目的探讨三阴性乳腺癌(TNBC)的临床病理特征。方法回顾性分析4年间资料完整的3 8例TNBC患者临床资料,包括患者的一般状况、病理特点、分子标志物、复发与转移状况,并与同期非TNBC进行比较。结果≤35岁的患者在TNBC及非TNBC中分别占21.05%(8/38)和5.14%(15/292)(P<0.05)。TNBC组中有淋巴结转移者60.53%(23/38),高于非TNBC的43.49%(127/292)(P<0.05),TNBC组中组织学III级者52.63%(20/38)高于非TNBC组的35.27%(103/292)(P<0.05),TNBC中有瘤周脉管侵犯者占31.58%(12/38)高于非TNBC的15.41%(45/292)(P<0.05)。TNBC组表皮生长因子受体(EGFR)阳性率、血管内皮生长因子(VEGF)阳性率、E-钙黏附蛋白(E-cad)异常表达率分别为81.58%(31/38),78.95%(30/38),65.79%(25/38),高于非TNBC组的39.73%(116/292),61.30%(179/292),48.29%(141/292)(均P<0.05)。远处转移率在TN...
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| 关 键 词： | 乳腺肿瘤/病理学 三阴性乳腺癌 分子标志物 预后 |
| 收稿时间： | 2010-12-22 |
| 修稿时间： | 2011-06-14 |
Clinicopathological features of triple-negative breast cancer |
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| Affiliation: | (1.Department of General Surgery| Maanshan Municipal People′s Hospital| Maanshan| Anhui 243000| China|2. Department of General Surgery| Zhongda Hospital| Southeast University| Nanjing 210009| China) |
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| Abstract: | Objective To identify the clinicopathological features of triple-negative breast cancer(TNBC).Methods There were 38 TNBC patients with complete records available who were admitted to our hospital over a 4-year period.Their clinical data that included the general conditions,pathological features,molecular markers,recurrence and metastasis were retrospectively analyzed and were compared with those of non-TNBC patients admitted during the same period.Results In the TNBC and non-TNBC patients,the cases less tha... |
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| Keywords: | Breast Neoplasms/pathol Triple-negative Breast Cancer Molecular Marker Prognosis |
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