| 乳腺癌脑转移患者危险因素分析 |
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| 引用本文： | 曲明阳|李森|赵胜男|邢光明. 乳腺癌脑转移患者危险因素分析[J]. 中国普通外科杂志, 2011, 20(11): 1184-1187 |
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| 作者姓名： | 曲明阳|李森|赵胜男|邢光明 |
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| 作者单位： | 大连医科大学附属第二医院普通外科; |
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| 基金项目： | 大连市科技局资助项目(2010E15SF179) |
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| 摘 要： | 目的探讨影响乳腺癌脑转移的危险因素。方法对1997—2007年收治的乳腺癌患者进行随访,以发生脑转移的133例患者作为脑转移组,以未发生脑转移的145例患者作为对照组,就脑转移的相关因素进行对照分析。结果组织学分级为3级,肿瘤长径大于5 cm,雌激素受体(ER)阴性,人表皮生长因子受体(HER-2)阳性的乳腺癌患者容易发生脑转移;肿瘤分期,病理类型,孕激素受体(PR),腋窝淋巴结转移情况及绝经与否与脑转移无关(P>0.05)。结论组织学分级,肿瘤大小,HER-2是乳腺癌患者发生脑转移的独立危险因子;ER可能是乳腺癌脑转移的独立保护因子。
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| 关 键 词： | 乳腺肿瘤 肿瘤转移 脑 雌激素受体 孕激素受体 人表皮生长因子受体 Logistic模型 |
| 收稿时间： | 2011-05-10 |
| 修稿时间： | 2011-07-13 |
Risk factors for brain metastases of patients with breast cancer |
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| QU Mingyang| LI Sen| ZHAO Shengnan| XING Guangming. Risk factors for brain metastases of patients with breast cancer[J]. Chinese Journal of General Surgery, 2011, 20(11): 1184-1187 |
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| Authors: | QU Mingyang| LI Sen| ZHAO Shengnan| XING Guangming |
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| Affiliation: | QU Mingyang,LI Sen,ZHAO Shengnan,XING Guangming(Departament of General Surgery,the Second Affiliated Hospital,Dalian Medical University,Dalian,Liaoning 116027,China) |
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| Abstract: | Objective To determine the risk factors of brain metastases of patients with breast cancer.Methods Follow-up surveys were carried out in the patients with breast cancer who were treated at our hospital from 1997 to 2007.Of the patients,133 cases having brain metastasis were considered as the study group and the other 145 cases without brain metastasis served as the control group.The factors related to brain metastasis were comparatively analyzed.Results The likelihood of brain metastasis of patients with br... |
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| Keywords: | Breast Neoplasms Neoplasm Metastasis Brain Estrogen Receptor Progesterone Receptor Human Epidermal Growth Factor Receptor-2 Logistic Models |
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