肾移植病人应用霉酚酸酯与硫唑嘌呤的临床疗效比较

目的：比较霉酚酸酯（MMF）、硫唑嘌呤（Aza）在肾移植病人中的临床效果。方法：肾移植术后服用霉酚酸酯、硫唑嘌呤患者各28例，均采用同服环孢菌素和泼尼松三联用药方案，每月常规监测环孢菌素A（CsA）全血浓度、血常规、肾功能、肝功能、尿常规。结果：MMF组的CsA用量及其血药浓度显著低于Aza组（P〈0．05），MMF组患者血肌酐（Cr）值也显著低于Aza组（P〈0．05），同时MMF组对急慢性排斥反应效果较Aza组好，药物性肝损害发生率低于Aza组。结论：MMF较Aza不良反应小，减少或避免肝、肾功肾功能损害的发生机会，使肾移植的成功率明显提高。

Comparison of clinical therapeutic effects of mycophenolate mofetil and azathioprine in patients after renal transplantation

AIM:To compare the clinical therapeutic effects of mycophenolate mofetil(MMF) with those of azathioprine on kidney graft recipients after renal transplantation.METHODS:56 patients were randomly divided into 2 groups: the group MMF and the group Aza(n=28 in each group).In the group MMF,the patients were subjected to MMF,together with cyclosporin A(CsA)and prednisone(Pred).In the group Aza,the patients received the triple drug treatment protocol: Aza,CsA and Pred.The whole blood concentration of CsA,function of the liver and the kidney as well as routine urine test were monitored at each monthly interval.RESULTS:The required administration of CsA and its blood concentration were remarkably lower in the group MMF than those in the group Aza(P<(0.05)).Compared with the group Aza,the serum level of creatinine in the group MMF was also significantly lower(P<(0.05)).MMF had better therapeutic effects to resist acute rejections.The incidence of drug induced liver injury in the group MMF was lower as well.CONCLUSION:compared with Aza,MMF causes less adverse effects and induces less impairment on the liver and kidney.So MMF has better clinical therapeutic effects and can improve the survival rate of kidney grafts significantly.