Understanding the role of tumor stem cells in glioblastoma multiforme: a review article |
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| Authors: | Aalya Fatoo Michael J. Nanaszko Baxter B. Allen Christina L. Mok Elena N. Bukanova Robel Beyene Jennifer A. Moliterno John A. Boockvar |
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| Affiliation: | (1) Neurosurgical Laboratory for Translational Stem Cell Research, Department of Neurosurgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College of Cornell University, 510 E 70th Street, New York, NY 10021, USA;(2) Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; |
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| Abstract: | It has been hypothesized that cancer stem cells (CSC) may account for the pathogenesis underlying various tumors, including GBM. Markers of these CSCs can be potentially used as therapeutic targets. In this review, we discuss the most recent information regarding CSCs, their molecular biology and their potential role in GBM. |
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