壳寡糖对兔腓总神经损伤的影响

目的:研究壳寡糖(COSs)对兔周围神经损伤的修复作用。方法:对32只健康成年兔行腓总神经夹伤术。再分为4组:COSs高、低剂量组(剂量3mg/kg及1.5mg/kg),弥可保组(阳性对照,剂量30μg/kg),空白对照组(给予等体积双蒸水),均耳缘静脉给药6周,行Meyer's改良神经三色染色和透射电镜观察。结果:COSs高、低剂量组再生髓鞘数目显著优于空白对照组(P<0.01)。超微结构观察显示COSs高、低剂量组再生神经的髓鞘形态明显优于空白对照组,变性纤维数少于空白对照组。结论:COSs能促进兔腓总神经夹伤后的再生。

Effects of chitooligosaccharides on the crushed common peroneal nerve of rabbits

Objective:To study the regeneration effect of chitooligosaccharides (COSs) on the crushed common peroneal nerve of rabbits. Methods: Thirty-two New Zealand adult rabbits suffering common peroneal nerve crush were used in the experiment. The animals were randomly divided into four groups: two COSs groups (low and high dose), Methycobal group (positive control) and control group. Histochemistry and ultra-structure were studied after treating for six weeks. Results: The number of regeneration nerve fibers and maturity of regeneration myelinated nerve sheath in the COSs were more than those in the control group (P<0.01). But the number of degeneration nerve fibers following nerve injury was fewer than that in the control group by electron microscope observation. Conclusion: NRF promotes the regeneration of peripheral nerve and the recovery of function.