RmhTNF联合顺铂与单用顺铂胸腔注射治疗恶性胸腔积液的比较

目的研究重组改构肿瘤坏死因子(rmhTNF) 顺铂及单用顺铂治疗恶性胸腔积液的疗效及毒性反应。方法两组所有病例均先采用中心静脉管胸腔置管术,胸水引流干净后,胸腔内分别注入rmhTNF 顺铂或单用顺铂,观察两组疗效及毒性反应。结果rmhTNF 顺铂组治疗恶性胸腔积液的有效率为92.5%,单用顺铂组为80.6%;两组毒副反应发生率分别为39.6%和41.9%。结论rmhTNF 顺铂组治疗恶性胸腔积液的疗效优于单用顺铂组,而毒副反应无差别。

Clinical observation on rmhTNF plus cisplatin compared with cisplatin alone in the treatment of malignant pleural cavity effusion

Objective: To study the efficacy and adverse effects of rmhTNF plus cisplatin and cisplatin alone in the treatment of malignant pleural cavity effusion. Methods: All patients diagnozed as malignant pleural cavity effusion by cytology were divided into therapy group and control group, and they were given the close drainage. When malignant pleural cavity effusion was drained mainly, rmhTNF plus cisplatin were inculcated in the therapy group while cisplatin inculcated in the control group.To observe the efficacy and adverse effects in the two groups. Results: Thirty one patients showed CR and 18 patients showed PR in the therapy group, giving an effective rate of 92.5% and a toxicity occured rate of 39.6%; 9 patients showed CR and 16 patients showed PR in the control group, giving an effective rate of 80.6% and a toxicity occured rate of 41.9%. Conclusion: The efficacy of rmhTNF plus cisplatin group is better than cisplatin alone group. There were no significant differences in the incidence of side effects and toxic effects between the two groups.