T2 mapping and dGEMRIC after autologous chondrocyte implantation with a fibrin-based scaffold in the knee: Preliminary results |
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Authors: | SE Domayer GH Welsch S Nehrer C Chiari R Dorotka P Szomolanyi TC Mamisch S Trattnig |
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Institution: | a Department of Orthopedics, Medical University of Vienna, Währinger Gürtel 18-20, A 1090 Vienna, Austria b MR Centre of Excellence, Department of Radiodiagnostics, Medical University of Vienna, Lazarettgasse 14, A-1090 Vienna, Austria c Centre of Regenerative Medicine, Danube University of Krems, Dr.-Karl-Dorrek-Straße, 30 A-3500 Krems, Austria d Institute of Measurement Science, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia e Department of Orthopedics, Inselspital, University of Bern, 3010 Bern, Switzerland f ProChon Biotech Ltd., Weizmann Science Park, Nes Ziona, Israel |
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Abstract: | ObjectiveTo assess repair tissue (RT) after the implantation of BioCart™II, an autologous chondrocyte implantation (ACI) technique with a fibrin-hyaluronan polymer as scaffold. T2 mapping and delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) were used to gain first data on the biochemical properties of BioCart™II RT in vivo.MethodsT2 mapping and dGEMRIC were performed at 3 T in five patients (six knee joints) who had undergone ACI 15-27 months before. T2 maps were obtained using a pixel wise, mono-exponential non-negative least squares fit analysis. For quantitative T1 mapping a dual flip angle 3D GRE sequence was used and T1 maps were calculated pre- and post-contrast using IDL software. Subsequent region of interest analysis was carried out in comparison with morphologic MRI.ResultsA spatial variation of T2 values in both hyaline, normal cartilage (NC) and RT was found. Mean RT T2 values and mean NC T2 values did not differ significantly. Relative T2 values were calculated from global RT and NC T2 and showed a small range (0.84-1.07). The relative delta relaxation rates (rΔR1) obtained from the T1 maps had a wider range (0.77-4.91).ConclusionT2 mapping and dGEMRIC provided complementary information on the biochemical properties of the repair tissue. BioCart™II apparently can provide RT similar to hyaline articular cartilage and may become a less-invasive alternative to ACI with a periosteal flap. |
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Keywords: | Cartilage repair dGEMRIC T2 mapping High field MRI ACI |
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