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Effects of Scutellariae radix and Aloe vera gel extracts on immunoglobulin E and cytokine levels in atopic dermatitis NC/Nga mice |
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| Authors: | Jinkyung Kim Soojin Park |
| Institution: | a Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, Republic of Korea b Department of Oriental Medical Food and Nutrition, Semyung University, 117 Semyung-ro, Jecheon, Chungbuk, Republic of Korea c Research Institute of Clinical Nutrition, Kyung Hee University, Dongdaemoon-gu, Seoul 130-701, Republic of Korea |
| Abstract: | Aim of the studyThe present study aimed to investigate the effects of Scutellariae radix (SR) and Aloe vera gel (AV), alone or in combination, on levels of immunoglobulin E (IgE) and inflammatory cytokines in spontaneous atopic dermatitis(AD)-like skin lesions.Materials and methodsAfter spontaneous AD-like skin lesion was developed by adaptation to conventional conditions, mice were randomly assigned to control, SR (50 mg/kg, p.o.), AV (0.8 mg/kg, p.o.) and SRAV (50 mg of SR and 0.8 mg of AV/kg, p.o.) groups, and were treated for 6 weeks.ResultsSR and SRAV suppressed IL-5 levels compared with control, but had no effects on IgE levels (P < 0.05). AV increased IgE levels, but decreased both IL-5 and IL-10 compared with control (P < 0.05).ConclusionThese results suggest that SR and AV modulate immunological responses in AD, mainly through influencing IL-5 or IL-10 levels. |
| Keywords: | Atopic dermatitis Aloe vera gel Cytokines IgE Scutellariae radix |
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