血清总胆汁酸在新生儿溶血患者肝损害中的临床观察

目的进一步证实血清总胆汁酸洲定住评价新生儿溶血患者肝损害中的临床价值。方法用酶循环法测定68例新生儿溶血病患者血清总胆汁酸，同时检测总胆红素、丙氨酸移基转移酶、碱性磷酸酶、L-γ-符氨酰基转移酶。结果溶血组患者血清总胆汁酸水平为（27．63±4．83）mmol／L，对照组为（14．92±6．87）mmol／L。两组水平比较，差异有统计学意义（P〈0．01）。异常检出率高达70．59％（48／68）。与总胆红素、丙氨酸氨基转移酶、碱性磷酸酶、1．7-谷氨酰基转移酶等肝功能指标呈正相关。结论血清总胆汁酸可作为新生儿溶血病患者肝损害疗效观察及预后判断的检测指标。

Clinical value of determination of serum total bile acid in hepatic lesion in hemolytic disease of the newborn

Objective To further confirm the clinical value of serum total bile acid (TBA) in hepatic lesion in patients with hemolytic disease of the newborn.Methods Enzyme circulation assay was applied to measuring in 68 patients with hemolytic disease of the newborn. Total bilirubin (TBIL), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT) were measured simultaneously.Results The serum level of TBA was (27.63±4.83) mmol/L in haemolysis group, significantly higher than that in control group (14.92±6.87) mmol/L (P<0.01). The positive rate accounted for 70.59% (48/68) in haemolysis group, and serum level of TBA was positively correlative with liver functional parameters (TBIL, ALT, GGT and ALP).Conclusion Serum TBA may be used as an indicator of therapeutic effect monitoring and prognosis evaluation of hepatic lesion in patients with hemolytic disease of the newborn.