| 雷公藤多甙对动脉内皮损伤大鼠血浆内洋地黄因子的影响 |
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| 引用本文： | 秦玉明 牛峰海. 雷公藤多甙对动脉内皮损伤大鼠血浆内洋地黄因子的影响[J]. 济宁医学院学报, 1995, 18(3): 15-17 |
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| 作者姓名： | 秦玉明 牛峰海 |
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| 作者单位： | Department of Pediatrics Affiliated Hospital，Jining Medical College |
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| 摘 要： | 利用金属管基的充液球囊导管，制造大鼠胸、腹主动脉内皮损伤模型。采用放射免疫分析法测定大鼠血浆内源性类洋地黄因子含量，同时用光镜观察大鼠胸主动脉内皮损伤后的病理变化，并观察雷公藤多甙对血管内皮损伤和血浆ＥＤＬＦ含量的影响。结果显示血管内皮损伤后ＥＤＬＦ含量明显升高，血管内皮损伤局部附着较多炎性细胞。
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| 关 键 词： | 类洋地黄因子 内源性 血管内皮 雷公藤多甙 大鼠 |
EFFECT OF TRIPTERYGIUM WILFORDII GLYCOSIDES ON PLASMA ENDOGENOUS DIGIT ALIS-LIKE FACTOR IN AORTIC ENDOTHELIUM INJURY IN RATS |
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| Qin Yuming,et al.. EFFECT OF TRIPTERYGIUM WILFORDII GLYCOSIDES ON PLASMA ENDOGENOUS DIGIT ALIS-LIKE FACTOR IN AORTIC ENDOTHELIUM INJURY IN RATS[J]. Jounal of Jinning Medical College, 1995, 18(3): 15-17 |
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| Authors: | Qin Yuming et al. |
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| Abstract: | In this study,we created the rat model of aortic endothelium injury with homemade endothelium injury catheter.The plasma level of Endogenous Digitalis-Like Factor(EDLF)in rats was measured by radioimmunoassay.We observed the pathological changes in thoraco-aortic endothelium in each group.The results showed that plasma level of EDLFwas raised in injured aortic endothelium in rats.The inflammatory reaction caused by vascular endothelium injury was inhibited and the raised plasma level of EDLF lowered significantly by using Tripterygium Wilfordii Glycosides.The results suggested there was inflammatory reaction in the injured vascular endothelium and the Tripterygium wilfordii Glycosides might be able to alleviate the endothelium injury by inhibiting inflammatory reaction and immune reaction, resulting in the lowering of the raised plasma level of EDLF. |
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| Keywords: | Endogenous digitalis-like factor Aortic endothelium injury Tripterygium wilfordii glycosides |
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