氯沙坦对高血压及左心室肥厚影响观察

目的观察氯沙坦的降血压效果及其对左心室重塑的影响。方法30例高血压（EH）伴左心室肥厚（LVH）患者口服氯沙坦50-100 mg,每日1次,总疗程16周。经心脏彩色超声多普勒（UCG）检查心脏结构2次,观察其对左心室重塑的影响,同时监测药物不良反应。结果EH并伴有LVH患者治疗后血压下降总有效率达80%,P〈0.01。UCG提示左心室重量指数（LVMI）治疗后下降明显,P〈0.05。结论氯沙坦长期应用能在降血压的同时逆转左心室肥厚,是一种很好的改变左心室重塑的药物之一。

Effects of losartan on hypertension and left ventricular hypertrophy

Objective To observe the effects of losartan on hypertension and left ventricular hypertrophy. Methods Thirty patients with essential hypertension （ EH ） with left ventricular hypertrophy （ LVH ） were treated with oral losartan 50 - 100mg, once a day, with a total 16 week course of treatment. The heart structure was checked twice throngh color Doppler ultrasonic cardiography （UCG） to observe the effects of left ventricular remodeling and at the same time to monitor adverse drug reactions. Results EH and LVH showed fine results after the treatment. The blood pressure dropped and the total effective rate was 80% （ P 〈 0.01 ）. UCG indicated the left ventricular mass index （LVMI） decreased significantly after the treatment （ P 〈 0.05 ）. Conclusion The long-term use of losartan contributes to blood pressure decrease and reversed left ventricular hypertrophy. It is one of the advisable drugs for left ventricular remodeling.