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The anterolateral funiculus in the spinal cord in amyotrophic lateral sclerosis
Authors:Kiyomitsu Oyanagi  Takao Makifuchi  Fusahiro Ikuta
Affiliation:(1) Brain Disease Research Center, Brain Research Institute, Niigate University, I Asahimachi, 951 Niigata, Japan;(2) Division of Neuropathology, National Saigata Hospital, Oogata, 949-31 Niigata, Japan;(3) Department of Pathology, Brain Research Institute, Niigata University, 951 Niigata, Japan;(4) Present address: Niigata Neurosurgical Hospital and Brain Research Center, Kurosaki, 950-11 Niigata, Japan
Abstract:We carried out a morphometric study on the myelinated fibers in the anterolateral funiculus (ALF) and lateral corticospinal tract (LCS) in the cervical segment of the spinal cord of 13 patients with classic amyotrophic lateral sclerosis (ALS), 6 of whom had been on a respirator: 5 age-matched subjects were used as controls. The results obtained revealed that: (1) the fiber-size distributions of the myelinated fibers in the ALF and LCS of the control subjects had peaks at 2 mgrm; (2) there were marked and significant losses of large myelinated fibers in the ALF and LCS of ALS patients; (3) the patients who required respirator support showed more severe degeneration in the ALF than those who required none; and (4) the degree of myelinated fiber loss in the LCS did not correlate with either the illness duration or the history of respirator use.
Keywords:Amyotrophic lateral sclerosis  Anterolateral funiculus  Lateral corticospinal tract  Myelinated fiber  Morphometry
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