Micro- and macro-consequences of ooplasmic injections of early haploid male gametes |
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| Authors: | Sofikitis N; Miyagawa I; Yamamoto Y; Loutradis D; Mantzavinos T; Tarlatzis V |
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| Institution: | 0 Reproductive Physiology and IVF Center, Department of Urology, Tottori University School of Medicine, Yonago 683, Japan
2 A/B Departments of Obstetrics and Gynecology, Athens University School. of Medicine, Athens, Greece
3 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece
1 Corresponding author |
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| Abstract: | This review refers to the evolution of ooplasmic injectionsof round spermatid nuclei ROSNI) or intact round spermatidsROSI). Conclusions from their preliminary application in thehamster, rabbit, mouse and human are discussed. Criteria foridentification of round spermatids and guidelines/quality controlfor application of ROSNI/ROSI techniques are emphasized. Althoughall the animal offspring and the human newborns delivered afterROSNI/ROSI are healthy additional research efforts are necessaryto confirm the safety of these procedures and improve theiroutcome |
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| Keywords: | ROSNI/spermatids/spermatogenesis |
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