肺鳞癌组织中磷脂酶A2蛋白表达的相关性及临床病理意义

目的 探讨分泌型磷脂酶A2(sPLA2-Ⅱa)及胞浆型磷脂酶A2(cPLA2)蛋白表达与肺鳞癌发生、发展及浸润、转移的关系.方法 应用免疫组织化学S-P法检测60例肺鳞癌组织及20例正常肺黏膜组织中sPLA2-Ⅱa及cPLA2蛋白表达.结果 肺鳞癌组织中sPLA2-Ⅱa(68.3%)及cPLA2(61.7%)蛋白阳性表...

The Correlation and Clinical Pathological Significance of the Expressions of Phospholipase A2 Proteins in Lung Squamous Cell Carcinoma

Objective To explore the relationship of the expressions of secretory phospholipase A2(sPLA2-Ⅱa) and cytosolic phospholipase A2(cPLA2) proteins and the occurrence,development,invasion and metastasis in lung squamous cell carcinoma.Methods S-P immunohistochemical method was used to detect the expressions of sPLA2-Ⅱa and cPLA2 protein in 60 cases of lung squamous cell carcinoma tissues and 20 cases of normal lung epithelium tissues.Results The positive expression rates of sPLA2-Ⅱa(68.3%) and cPLA2(61.7%) proteins in lung squamous cell carcinoma tissues were obviously higher than those in normal lung epithelium tissues(protein positive ratios: 15.0% and 10.0%),there were significant differences among the groups(χ2=17.239 and 16.027,P<0.05).The sPLA2-Ⅱa protein positive expression rate was closely correlated with the histological grade,TNM grade and lymphatic metastasis in lung squamous cell carcinoma tissues(χ2=9.243,4.501 and 8.287;P<0.05).The cPLA2 protein positive expression rate was closely correlated with the histological grade,TNM grade and lymphatic metastasis in lung squamous cell carcinoma tissues(χ2=6.160,8.013 and 4.785;P<0.05).There was positive correlation between the protein expressions of sPLA2-Ⅱa and cPLA2(r=0.274,P<0.05).Conclusion sPLA2-Ⅱa and cPLA2 can play important roles in the infiltration,metastasis and carcinomatous change of the mucosa epithelium in lung squamous cell carcinoma.United examining sPLA2-Ⅱa and cPLA2 can become one of molecular index in the early diagnosis and prognostic judgement of lung squamous cell carcinoma.