| 阿仑膦酸钠对破骨细胞分化中c-fos基因表达的影响 |
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| 引用本文： | 王立,戚孟春,刘彩霞,董伟.阿仑膦酸钠对破骨细胞分化中c-fos基因表达的影响[J].医学研究杂志,2011,40(7):71-74. |
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| 作者姓名： | 王立 戚孟春 刘彩霞 董伟 |
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| 作者单位： | 1. 河北联合大学口腔医学院,唐山,063000
2. 河北省唐山市口腔医院 |
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| 基金项目： | 河北省科学技术研究与发展计划项目 |
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| 摘 要： | 目的探讨阿仑膦酸钠对破骨细胞分化中c-fos基因的作用机制。方法将不同浓度的阿仑膦酸钠作用于小鼠破骨细胞,采用Western blot检测小鼠破骨细胞分化中c-fos基因的表达情况。结果阿仑膦酸钠组TRAP阳性破骨细胞数目和c-fos基因的表达显著低于空白对照组;且加入10-4mol/L、10-6mol/L、10-8mol/L浓度阿仑膦酸钠后,c-fos表达受抑制程度依次增强;而在10-8mol/L、10-10mol/L、10-12mol/L浓度中,c-fos表达受抑制程度依次减弱。结论阿仑膦酸钠可使破骨细胞分化中的c-fos基因受到抑制,其抑制程度与阿仑膦酸钠的浓度有关,10-8mol/L浓度时抑制作用最强。
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| 关 键 词： | 阿仑膦酸钠 c-fos 破骨细胞 Western blot |
| 收稿时间： | 2010/11/14 0:00:00 |
| 修稿时间： | 2011/5/13 0:00:00 |
Effect of Alendronate Sodium on c-fos Gene in Osteoclast Differentiation |
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| Wang Li,Qi Mengchun,Liu Caixia,Dong Wei.Effect of Alendronate Sodium on c-fos Gene in Osteoclast Differentiation[J].Journal of Medical Research,2011,40(7):71-74. |
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| Authors: | Wang Li Qi Mengchun Liu Caixia Dong Wei |
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| Institution: | Wang Li,Qi Mengchun,Liu Caixia,Dong Wei.School of Stomatology Heberi United University,Hebei 063000,China |
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| Abstract: | Objective To study the probably mechanism of alendronate sodium to c-fos gene in osteoclast differentiation.Methods Different concentrations of alendronate sodium had effect on mice osteoclast.c-fos expression in mouse osteoclast differentiation was detedcted using Western blot.Results The number of TRAP+ osteoclasts and the expression of c-fos gene from alendronate group were significantly lower than those in control group(P<0.05),and the expression of c-fos was enhanced with the concentration increase of ... |
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| Keywords: | c-fos Western blot |
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