| 5-HTTLPR基因多态性与2型糖尿病关联性研究 |
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| 引用本文： | 秦永章,荣海钦,季虹,胡敬,张勇,郭振奎.5-HTTLPR基因多态性与2型糖尿病关联性研究[J].医学研究杂志,2011,40(7):88-90. |
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| 作者姓名： | 秦永章 荣海钦 季虹 胡敬 张勇 郭振奎 |
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| 作者单位： | 山东省内分泌与代谢病研究所,济南,250062 |
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| 摘 要： | 目的探讨山东汉族人群2型糖尿病与5-羟色胺转运体启动子区基因多态性(5-HTTLPR)的关系。方法选取387例2型糖尿病患者和286例对照个体,采用聚合酶链反应(PCR)技术检测5-HTTLPR多态性。结果 LS基因型和SS基因型在病例组所占比例(74.2%)明显高于对照组(62.9%)(P<0.01),5-HTTLPR等位基因频率分布两组之间差异具有统计学意义(P<0.05);S等位基因明显增加患2型糖尿病的遗传风险性(OR=1.73,95%可信区间1.24~2.43,P<0.01)。结论 5-HTTLPR基因多态性可能与2型糖尿病相关。
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| 关 键 词： | 5-HTTLPR基因 基因多态性 2型糖尿病 |
| 收稿时间： | 2010/10/17 0:00:00 |
Relationship between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Type 2 Diabetes Mellitus |
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| Qin Yongzhang,Rong Haiqin,Ji Hong,Hu Jing,Zhang Yong,Guo Zhenkui.Relationship between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Type 2 Diabetes Mellitus[J].Journal of Medical Research,2011,40(7):88-90. |
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| Authors: | Qin Yongzhang Rong Haiqin Ji Hong Hu Jing Zhang Yong Guo Zhenkui |
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| Institution: | Qin Yongzhang,Rong Haiqin,Ji Hong,Hu Jing,Zhang Yong,Guo Zhenkui.Shandong Institute of Endocrine and Metabolic Diseases,Shandong 250062,China |
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| Abstract: | Objective To investigate the relationship between the serotonin transporter promoter polymorphism(5-HTTLPR) and type 2 diabetes mellitus in the Chinese Han population from Shandong province.Methods The study selected 387 subjects diagnosed with type 2 diabetes mellitus and 286 non-diabetic subjects.The PCR technology was used to examine the 5-HTTLPR polymorphism.Results The frequency of LS and SS genotypes of the 5-HTTLPR was significantly higher in the cases(74.2%) than in the controls(62.9%)(P<0.01).And s... |
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| Keywords: | 5-HTTLPR gene Gene polymorphism Type 2 diabetes mellitus |
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