成人原发性甲减患者血浆SS、SP含量的变化

目的:观察成人原发性甲状腺机能减退(甲减)患者甲状腺素(TH)治疗前后脑神经肽变化,以探索甲减致脑中枢神经系统损害的机制。方法:采用放射免疫分析,对比分析了45例成人原发性甲减患者TH治疗前后血浆中生长抑素(SS)、P物质(SP)变化。结果:甲减组血浆中SP水平明显低于正常对照组(P<0.01),SS水平与正常对照组比较无显著性差异(P>0.05),其中FT3≥2.5pmol/L组病人血浆中SS水平与正常对照组比较无显著性差异(P>0.05),FT3<2.5pmol/L组血浆中SS含量低于正常对照组(P<0.05),经过TH治疗后SS、SP水平提高(P<0.05,P<0.01)。结论:成人原发性甲减患者血浆存在不同程度的SS、SP减低,这与其引起的神经精神症状可能密切相关,早期、积极、正规的TH治疗对脑功能的恢复有很重要的意义。

Changes of Plasma SS.SP Contents in Adult Patients with Primary Hypothyroidism

Objective To investigate the possible mechanism of imparirment of central nervous system function in hypothyroid patients through determination of changes of plasma neuropeptides after thyroid hormone replacement therapy.Methods Plasma somatostatin(SS) and substance P(SP) contents were measured with RIA in 45 patients with primary hypothyroidism both before and after thyroid hormone replacement therapy as well as in 38 controls.Results Before treatment,the plasma contents of SP in the patients were significantly lower than those in the controls(P<0.05) but plasma SS contents in the patients were not much different from those in controls(P>0.05).However,the plasma contents of SS in the more advanced hypothyroid patients with FT3<2.5pmol/L(27/45) were significantly lower than those in controls(P<0.05).After two months'hormone replacement therapy with normalization of the FT3,FT4 levels,the plasma SS,SP increased significantly(vs before treatment P<0.05,P<0.01).Conclusion The decrease of plasma contents of SS and SP in patients with hypothyroidism might be related to the development of psycho-neurological symptoms in these patients and thyroid hormone replacement therapy was desirable.