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| 中药藿香正气水对大鼠结肠平滑肌收缩的机理研究 | |
| 引用本文： | 李康,陈思亮,周文良,王媛媛.中药藿香正气水对大鼠结肠平滑肌收缩的机理研究[J].中国实验方剂学杂志,2010,16(5):131-134. |
| 作者姓名： | 李康 陈思亮 周文良 王媛媛 |
| 作者单位： | 1. 药科学院,广东药学院,广州,510006 2. 中山大学生命科学学院,广州,510275 3. 临床医学院,广东药学院,广州,510006 |
| 基金项目： | 国家自然科学基金杰出青年科学基金，中国博士后科学基金，广东省自然科学基金博士启动基金 |
| 摘 要： | 目的 :探索中药藿香正气水肠道作用机理。 方法 :运用肌肉张力测量技术研究藿香正气水对大鼠结肠平滑肌收缩的影响。 结果 : 藿香正气水能够抑制由激动剂—卡巴胆碱(CCH)和KCl引起大鼠结肠平滑肌的收缩。 结论: 藿香正气水抑制收缩的作用与抑制平滑肌细胞膜上钙通道的开放是相关的。 |
| 关 键 词： | 藿香正气水 肠道 机理 肌肉张力 |
| 收稿时间： | 1/4/2010 12:00:00 AM |
Mechanism of Effect of Huoxiang Zhengqi Liquid on the Spontaneous Contraction of Colonic Muscle From Mice |
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| LI Kang,CHEN Si-liang,ZHOU Wen-liang and WANG Yuan-yuan.Mechanism of Effect of Huoxiang Zhengqi Liquid on the Spontaneous Contraction of Colonic Muscle From Mice[J].China Journal of Experimental Traditional Medical Formulae,2010,16(5):131-134. | |
| Authors: | LI Kang CHEN Si-liang ZHOU Wen-liang and WANG Yuan-yuan |
| Institution: | College of Pharmacy, Guangdong Pharmaceutical Univercity, Guangzhou 510006,China;College of Life Science, Sun Yat-sen University, Guangzhou 510275,China;College of Life Science, Sun Yat-sen University, Guangzhou 510275,China;College of Clinical Medicine, Guangdong Pharmaceutical Univercity, Guangzhou 510006,China |
| Abstract: | Objective: To study the intestinal mechanism of Huoxiang Zhengqi Liquid (HZL). Method : The spontaneous contraction of colonic muscle from mice were studied using muscle tension measurement technology. Result : HZL could inhibit the spontaneous contraction caused by CCH or KCl of colonic muscle from mice. Conclusion: The effect of HZL on the spontaneous contraction is related with inhibition of Ca2+ channel. |
| Keywords: | Huoxiang Zhengqi Liquid intestinal mechanism muscle tension |
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