非那雄胺与度他雄胺在前列腺等离子电切术中的应用

目的研究非那雄胺与度他雄胺在前列腺等离子电切术（TUPKP）运用的有效性及安全性。方法将行 TUPKP 的147例患者分为非那雄胺组（45例）、度他雄胺组（39例）和对照组（63例）。非那雄胺组：术前服用非那雄胺5 mg/ d 超过6个月；度他雄胺组：术前服用度他雄胺0.5 mg/ d 超过6个月；对照组：术前12个月内未服用任何抗雄药物。比较各组术前、术中及术后的临床资料。结果各组患者前列腺体积、国际前列腺症状评分、生活质量评分、最大尿流率及血红蛋白含量差异无统计学意义（ P ＞0.05）。非那雄胺组和度他雄胺组的手术出血量、手术时间、术中生理盐水冲洗量等指标明显少于对照组，差异有统计学意义（ P ＜0.05），而非那雄胺组与度他雄胺组差异无统计学意义（P ＞0.05）。结论长疗程运用非那雄胺、度他雄胺均可以减少大体积前列腺患者术中及术后出血性事件的发生，用药安全性良好，但是短疗程及围手术期用药的效果有待进一步研究证实。

Application of finasteride and dutasteride in transurethral plasmakinetic prostatectomy

Objective To investigate the validity and safety of finasteride and dutasteride in transurethral plasmakinetic prostatecto-my(TUPKP). Methods In this study,147 patients who received transurethral plasmakinetic prostatectomy were divided into three groups:finasteride group(45 cases),which were treated for at least six months with finasteride 5mg daily before operation;dutasteride group(39 ca-ses),which were treated for at least six months with dutasteride 0. 5 mg daily before operation,and control group(63 cases),which were treated without any anti - androgen drugs before operation. The clinical data of the 147 patients before and after operation were analysed. Re-sults The volume of intraoperative bleeding,the operation time and the saline used for bladder infusion of the finasteride group and the dutasteride group were less than those of control group(P < 0. 05). There were no significant differences in the volume of intraoperative bleed-ing,the operation time and the used for bladder infusion of the finasteride group and those of control group(P > 0. 05). Conclusion Long term treatment of finasteride and dutasteride can all reduce the bleeding events during and after operation of TUPKP in patients,and the safety of the two drugs were good,but the effect of short course or perioperative period treatment of finasteride and dutasteride should be confirmed by further research.