| 溶血磷脂酸在卵巢癌细胞内HER2/neu的激活作用 |
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| 引用本文： | 叶璐,刘斌,李书华,张艺.溶血磷脂酸在卵巢癌细胞内HER2/neu的激活作用[J].临床和实验医学杂志,2013,12(8):570-571. |
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| 作者姓名： | 叶璐 刘斌 李书华 张艺 |
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| 作者单位： | 1. 广东省第二人民医院妇科 广东 广州510317
2. 广州医学院病理教研室 广东 广州510180 |
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| 基金项目： | 广东省医学科学技术研究基金课题 |
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| 摘 要： | 目的探索溶血磷脂酸(LPA)在卵巢癌细胞内HER2/neu的激活作用。方法通过免疫沉淀反应和蛋白印迹法检测卵巢癌细胞中HER2的变化。结果 LPA能诱导卵巢癌细胞中HER2的快速和瞬态的磷酸化。结论 LPA在卵巢癌细胞中作为HER2的上游分子,对卵巢癌细胞有强有力的刺激,可诱导卵巢癌细胞中HER2磷酸化。
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| 关 键 词： | 卵巢癌 溶血磷脂酸 HER2/neu |
The activation role of lysophospholipd acid in HER2/neu of human ovarian cancer cells |
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| Institution: | YE Lu1 , LIU Bin1 , LI Shu - hua2, et al. Department of Gynecology, Second People＇s Hospital of Guangdong Province, Guangzhou Guangdong 510317, China. 2. Department of Pathology, Guangzhou Medical College, Guangzhou Guangdong 510180, China. |
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| Abstract: | Objective The purpose of this study was to explore activation effect of lysophospholipd acid in HER2/neu of human ovarian cancer cell. Methods Changes of HER2 in ovarian cancer cells were analyzed by immune precipitation reaction and western blot. Results LPA can induce rapid and transient phosphorylation of HER2 in ovarian cancer cell. Conclusion LPA acts as upstream molecule of HER2 in ovarian cancer cell. The LPA may act as potent stimulator of ovarian cancer cell, and induce phosphorylation of HER2 in ovarian cancer cell. |
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| Keywords: | Ovarian cancer LPA HER2/neu |
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