Effect of amiridine and tacrine on the functional degeneration of the isolated neuron |
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Authors: | Yu V Burov A B Uzdenskii T N Robakidze |
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Institution: | (1) Russian Research Center for the Safety of Bioactive Compounds, Rostov-on-Don, USSR;(2) Institute of Neurocybernetics, Rostov-on-Don University, Rostov-on-Don, USSR |
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Abstract: | Amiridine and tacrine are found to have a concentration-dependent effect on the spontaneous activity of an isolated neuron
from crawfish. Amiridine in a concentration of 1 μM reliably prolongs the lifetime of the neuron, whereas lower concentrations
are inactive and a high concentration (10 μM) reduces spontaneous activity. Tacrine is unable to prolong the lifetime of the
neuron. It is suggested that, unlike tacrine, the therapeutic effect of amiridine stems from its ability to prolong neuronal
functioning.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp. 52–54, January, 1996
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences |
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Keywords: | amiridine tacrine action potential isolated neuron spontaneous activity |
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