| 内质网分子伴侣Grp94的表达与细胞周期的关系 |
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| 引用本文： | 赵迎辉 宋今丹. 内质网分子伴侣Grp94的表达与细胞周期的关系[J]. 中华物理医学与康复杂志, 1999, 21(2): 109-110 |
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| 作者姓名： | 赵迎辉 宋今丹 |
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| 作者单位： | 中国医科大学细胞生物学卫生部重点实验室 |
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| 摘 要： | 目的进一步分析正常组织来源的细胞系ＣＶ１和人大肠癌细胞系ＣＣＬ２２９的Ｇｒｐ９４的表达及其与细胞周期的关系。方法对细胞中ＤＮＡ和内质网分子伴侣Ｇｒｐ９４进行同时染色，进行双参数流式细胞术分析。结果两种细胞的Ｇｒｐ９４的表达情况相似，在细胞周期各时相中内质网分子伴侣Ｇｒｐ９４均有表达，Ｇ０＋Ｇ１期表达量较少，Ｓ期的表达量无明显增加，Ｇ２＋Ｍ期的表达量最高。结论Ｇｒｐ９４在细胞周期各时相的表达呈渐增的趋势，但在Ｓ期增加不明显，表明Ｇｒｐ９４的表达与细胞周期各时相的变化存在着密切的关系。
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| 关 键 词： | 内质网 细胞周期蛋白类 |
Expression of Grp94 in the cell cycle |
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| ZHAO Yinghui,SONG Jindan.Key Laboratory of Cell Biology of Public Health of China,China Medical University,Shenyang. Expression of Grp94 in the cell cycle[J]. Chinese Journal of Physical Medicine and Rehabilitation, 1999, 21(2): 109-110 |
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| Authors: | ZHAO Yinghui SONG Jindan.Key Laboratory of Cell Biology of Public Health of China China Medical University Shenyang |
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| Affiliation: | ZHAO Yinghui,SONG Jindan.Key Laboratory of Cell Biology of Public Health of China,China Medical University,Shenyang 110001 |
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| Abstract: | Objective To analyse the relationship of the expression of molecular chaperone Grp94 ER with cell cycle. Methods The expression of Grp94 related to the different stages was reported with Dualparameter flow cytometry methods. Results The expression of Grp94 was found during all stages of cell cycle.It was expressed at the lowest in G0-G1stage,a slightly higher level in S stage and the highest in G2-Mstage. Conclusion The expression of Grp94 is related to the stage of cell cycle. |
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| Keywords: | ndoplasmic reticulumCyclins |
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