The role of immune cells in metabolism-related liver inflammation and development of non-alcoholic steatohepatitis (NASH) |
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| Authors: | Marina Nati,David Haddad,Andreas L. Birkenfeld,Triantafyllos Chavakis |
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| Affiliation: | 1.Department of Clinical Pathobiochemistry, Faculty of Medicine,Technische Universit?t Dresden,Dresden,Germany;2.Section of Metabolic Vascular Medicine, Medical Clinic III, Faculty of Medicine,TU Dresden,Dresden,Germany;3.Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine,TU Dresden,Dresden,Germany;4.German Center for Diabetes Research (DZD e.V.),Neuherberg,Germany;5.Division of Diabetes and Nutritional Sciences, Rayne Institute,King’s College London,London,UK;6.Division of Endocrinology, Endocrine Tumor Program, Cancer Institute,University of Mississippi Medical Center,Jackson,USA;7.Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine,TU Dresden,Dresden,Germany |
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| Abstract: | The low grade inflammatory state present in obesity promotes the progression of Non-Alcoholic Fatty Liver Disease (NAFLD). In Non-Alcoholic Steatohepatitis (NASH), augmented hepatic steatosis is accompanied by aberrant intrahepatic inflammation and exacerbated hepatocellular injury. NASH is an important disorder and can lead to fibrosis, cirrhosis and even neoplasia. The pathology of NASH involves a complex network of mechanisms, including increased infiltration of different subsets of immune cells, such as monocytes, T-lymphocytes and neutrophils, to the liver, as well as activation and in situ expansion of liver resident cells such as Kupffer cells or stellate cells. In this review, we summarize recent advances regarding understanding the role of the various cells of the innate and adaptive immunity in NASH development and progression, and discuss possible future therapeutic options and tools to interfere with disease progression. |
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