硬脂酸改性纳米CaCO3对当归喷雾干燥粉体的影响研究

目的 研究硬脂酸改性纳米CaCO3,制备疏水性纳米CaCO3并应用于当归喷雾干燥粉体.方法 采用硬脂酸对纳米CaCO3进行表面改性,通过活化指数(H)、吸油值、接触角和透射电镜(TEM)、傅里叶变换红外光谱(FTIR)对改性前后纳米CaCO3进行分析和表征.以微粉硅胶和未改性纳米CaCO3为对照,考察改性纳米CaCO3对当归喷雾干燥粉体流动性、吸湿性和有效成分阿魏酸溶出行为的影响.结果 FTIR表明硬脂酸吸附在碳酸钙表面；改性后的纳米CaCO3改善当归喷雾干燥粉体流动性和吸湿性的效果优于微粉硅胶和未改性纳米CaCO3,且不影响阿魏酸体外溶出度.结论 经硬脂酸改性后的纳米CaCO3应用于中药喷雾干燥粉体值得进一步研究.

Effect of nano-CaCO3 modified with by stearic acid on spray drying powder of angelica

Objective To prepare hydrophobic nano-CaCO₃ modified by stearic acid and to study its application in spray drying power of angelica. Methods The stearic acid was used on the surface characteristic of nano-CaCO₃, and the modified and unmodified nano-CaCO₃ was analyzed and investigated by means of oil absorption value, activation index (H), angle of repose, transmission electron microscopy (TEM), and Fourier transforms infrared (FTIR). The effect of modified nano-CaCO₃ on moisture absorption, fluidity, and in vitro dissolution of ferulic acid in spray drying power of angelica were investigated, comparing with silicon dioxide and unmodified nano-CaCO₃. Results FTIR analysis showed that stearic acid has attached to CaCO₃ surface. Powder flow and powder moisture absorption were improved in modified nano-CaCO₃ and the effect was better than silica dioxide and unmodified nano- CaCO₃. The in vitro dissolution of ferulic acid was not affected. Conclusion The application of the nano-CaCO₃ modified by stearic acid in the spray drying power of Chinese materia medica deserves to be studied further.