老年2型糖尿病合并代谢综合征患者血清抵抗素水平与胰岛素抵抗的关系研究

目的探讨老年2型糖尿病合并代谢综合征(MS)患者空腹血清抵抗素水平与胰岛素抵抗的关系。方法选取老年2型糖尿病患者82例,其中46例合并MS(MS组),36例不合并MS(非MS组),另选取同期30例健康体检者作为对照组。检测3组受试者的空腹血清抵抗素水平,分别计算体质指数(BMI)、腰臀比(WHR)和胰岛素抵抗指数(HOMA-IR),并测定相关代谢指标,利用SPSS 13.0软件进行统计学分析。结果 MS组及非MS组糖尿病患者血清抵抗素水平及HOMA-IR均显著高于对照组,MS组患者上述两项指标亦显著高于非MS组,差异均有统计学意义(P<0.05)。多元逐步回归分析显示,抵抗素受HOMA-IR、WHR影响较大。结论老年2型糖尿病合并MS患者血清空腹抵抗素水平显著升高,且抵抗素水平与HOMA-IR及WHR呈正相关;抵抗素可能在胰岛素抵抗、肥胖和糖尿病中发挥重要作用。

Association of Serum Resistin with Metabolic Syndrome in Elderly Type 2 Diabetes Mellitus Patients

Objective To investigate the association of serum resistin(IR) with metabolic syndrome(MS) in elderly type 2 diabetes mellitus(T2DM) patients.Methods A total of 82 cases of elderly T2DM patientswere classified into MS group(n=46) and non-MS group(n=36).Another 30 healthy cases were selected as the control group.Body mass index(BMI) and waist/hip ratio(WHR) were calculated.Fasting serum resistin,insulin,glucose,HbA1c,UA,full lipid profile,and hs-CRP were determined.Statistical analysis was performed using SPSS 13.0 software.Results Serum resistin and HOMA-IR levels in MS group and non-MS group were significantly higher than those in the control group(both P<0.01).Significantly higher concentrations of resistin and hs-CRP,and HOMA-IR were observed in MS group than in non-MS goup(P<0.05).Multivariate stepwise regression analysis showed that HOMA-IR and WHR highly influenced the level of serum resistin.Conclusion Elderly T2DM patients with MS tend to have high fasting serum resistin.The resistin level is positively correlated with HOMA-IR and WHR.Resistin may play an important role in insulin resistance,obesity,and diabetes mellitus.