针灸治疗原发性抑郁症的疗效观察指标及其相关统计方法的计量分析研究

目的采用文献计量学方法对近10年针灸(含中西医结合)治疗原发性抑郁症现代文献进行分析,重点评价常用评价指标及其相关统计学方法,以指导临床及科研。方法制定文献的纳入标准、排除标准以及文献检索策略,检索中国期刊全文数据库等6个数据库,检索时间为2001年1月1日—2010年12月31日,获得相关文献后,对其进行常用评价指标和相关统计学方法的计量学研究。结果评价原发性抑郁症的指标以临床疗效、汉密尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)、副反应量表(TESS)和抗抑郁药副反应量表(SERS)为主;评价临床疗效的指标主要有HAMD减分率、SDS减分率、《常见疾病的诊断与疗效判定标准》等;统计学方法的使用中,计量资料多采用t检验,计数资料多采用χ2检验。结论目前从针灸治疗原发性抑郁症的文献研究中发现:其疗效评定指标不够全面,应从临床疗效(HAMD减分率评定法)、HAMD、SDS、SERS和世界卫生组织生存质量测定简表(WHO-QOL-BREF)五个方面进行综合评定;其相关统计学方法过于简单地使用t检验分析计量资料,χ2检验分析等级资料或计数资料,应根据资料类型、数据性质和研究目的等具体情况进行选择。

Indexes and Their Relevant Statistical Methods on Primary Disorder Treated with Acupuncture and Moxibustion:A bibliometric study

Objective The bibliometric method was taken to evaluate the common indexes and their relevant statistical methods in clinical treatment of primary depression by using acupuncture and moxibustion in recent 10 years.Methods Firstly,the inclusion criteria,exclusion criteria and literature retrieval strategy were formulated.Secondly,6 databases such as the Chinese Journal Full-text Database(CJFD),from 1 January 2001 to 31 December 2010,were searched,and the relevant literatures from these databases were sifted out.Finally bibliometric analysis was conducted for the common indexes and their statistical methods in the literatures.Results The indexes used to observe depressive disorders were mainly clinical effects,Hamilton Depression Rating Scale(HAMD),Self-Rating Depression Scale(SDS),Treatment Emergent Symptom Scale(TESS),and Asberg Rating Scale for Effects(SERS).The indexes to evaluate the clinical effects were mainly HAMD reducing rate,SDS reducing rate and Diagnosis and Therapeutic Effect Criteria of Common Diseases.For statistical method t test was mostly used in measurement data and χ2 test in enumeration data.Conclusion Through bibliometric study we find out that the observed indexes are not comprehensively chosen,so the clinical effects(HAMD reducing rate),HAMD,SDS,SERS and WHOQOL-BREF need to be used to comprehensively evaluate the therapeutic effects on depression;and a proper statistical method should be chosen according to the types and properties of data,and the study objective,rather than simply using t test for measurement data and χ2 test for enumeration data or ranked data.