TRIPTOSINE, AN L-5-HYDROXYTRYPTOPHAN DERIVATIVE, REDUCES ALCOHOL CONSUMPTION IN ALCOHOL-PREFERRING RATS |
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| Authors: | ERNOUF DOMINIQUE; DAOUST MARTINE; POULAIN DOMINIQUE; NARCISSE GUY |
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| Institution: | *U.F.R. de Pharmacie de Tours et Institut du Médicament de Tours B.P. 253, 37702 St Pierre-des-Corps Cedex, France
 Centre de Pharmacochimie, U.F.R. de Médecine et Pharmacie, St Etienne du Rouvray France
 Laboratoire Pan Médica Ivry-sur-Seine, France |
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| Abstract: | Triptosine is a new L-5-hydroxytryptophan derivative whose effecthas been studied in the Long-Evans alcohol-preferring rat. Atan oral dose of 100 mg/kg once daily, triptosine reduced alcoholconsumption by 42% in the second week of treatment and increasedthat of water by 80%. The results suggest that this precursorof serotonin might play an important role in diminishing preferencefor alcohol and reaccustoming the animal to water, without exertingan anorexic effect. |
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