| 金通宝胶丸的毒性和致突变性研究 |
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| 引用本文： | 林卫华,赵毓梅,郑定仙,黄业宇,王湛.金通宝胶丸的毒性和致突变性研究[J].中国热带医学,2003,3(6):728-730. |
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| 作者姓名： | 林卫华 赵毓梅 郑定仙 黄业宇 王湛 |
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| 作者单位： | 海南省疾病预防控制中心,海口市,570203 |
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| 摘 要： | 目的 研究金通宝胶丸的毒性和致突变性。 方法 采用急性毒性试验、小鼠骨髓微核试验、小鼠精子畸形试验、Ames试验和 3 0d喂养试验进行研究。 结果 雌雄大、小鼠急性经口LD50 >2 1 5 0g kg体重 ,属无毒级 ;小鼠骨髓微核试验、精子畸形试验和Ames试验三项致突变试验结果均为阴性 ,无明显致突变性 ;3 0d喂养试验未显示明显毒性。 结论 金通宝胶丸可安全食用
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| 关 键 词： | 金通宝胶丸 毒性 致突变性 研究 |
| 文章编号： | 1009-9727(2003)06-0728-03 |
| 修稿时间： | 2003年4月9日 |
Study on the toxicity and mutogenicity of Jintongbao capsule |
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| LIN Wei hua,ZHAO Yu mei,ZHENG Ding xian,et al,Hainan Provincial Center for Disease Control and Prevention,Haikou ,Hainan,P R China.Study on the toxicity and mutogenicity of Jintongbao capsule[J].China Tropical Medicine,2003,3(6):728-730. |
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| Authors: | LIN Wei hua ZHAO Yu mei ZHENG Ding xian Hainan Provincial Center for Disease Control and Prevention Haikou Hainan P R China |
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| Institution: | LIN Wei hua,ZHAO Yu mei,ZHENG Ding xian,et al,Hainan Provincial Center for Disease Control and Prevention,Haikou 570203,Hainan,P R China |
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| Abstract: | Objective To study the toxicity and mutagenicity of Jin Tongbao capsule Methods Acute toxicity test,Micronucieus test,Sperm shape abnormality test,Ames test and thirty days feeding tests were performed Results The determination of oral LD 50 in mice or rats was within the limit of nonpoisonous Mutagenic effect of Jin Tongbao capsule was assesed by Ames test,Micronucieus test and Sperm shape abnormality test,but the negative results were obtained There was no significant toxicity observed in thirty days tests Conclusion Jin Tongbao capsule is safe |
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| Keywords: | American Ginseng Lecithin Toxicity Mutagenicity |
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