Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis |
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| Authors: | S. V. Ramagopalan G. C. DeLuca K. M. Morrison B. M. Herrera D. A. Dyment M. R. Lincoln S.-M. Orton M. J. Chao A. Degenhardt M. Pugliatti A. D. Sadovnick S. Sotgiu Prof. G. C. Ebers |
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| Affiliation: | (1) Dept. of Clinical Neurology, University of Oxford, Level 3, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK;(2) Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;(3) Dept. of Medical Genetics and Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada;(4) Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy |
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| Abstract: | Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. As little is conclusively known about MS disease mechanisms, we have selected a variety of candidate genes that may influence the prognosis of the disease based on their function. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of on MS disease severity. The MS cases selected represent the prognostic best 5 % (benign MS) and worst 5 % (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that the genes selected have any outcome modifying activity, although small effects of these genes cannot be ruled out. |
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| Keywords: | multiple sclerosis genetics outcome |
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