肥胖儿童红细胞钙镁水平及ATP酶活性与高血压关系的探讨

目的

Relations between erythrocyte Ca~(2 ),Mg ~(2 ) levels and cell membrane ATPase activities in patients with hypertension in obese children

Objective To explore the roles of the metabolic disorders of cellular ions in pathogenesis of hypertension in obese children.Methods Erythrocyte membrane ATPase activities,plasma and cellular Ca 2 ,Mg 2 levels were measured in 125(37 non-obese normotensives,34 obese normotensives,21 hypertensives and 33 obese hypertensives)middle school students aged 12~16 years.Results Erythrocyte membrane Na -K -ATPase and Ca 2 -ATPase activities were significantly lower in obese children with normotension than those in non-obese normotensive children,and they were also significantly lower in two groups of hypertensive children than those in obese children with normotension.Erythrocyte Ca 2 in normotensive obese and two group of hypertensive children was significantly higher than that in non-obese normotensive children,but there were no significant differences between the three groups.There were no significant differences found in erythrocyte Mg 2 ,plasma Ca 2 and Mg 2 between normotensive obese and normotensive non-obese children,but significant decreases were found in both groups of hypertensive children.Conclusion Decreased Na -K -ATPase and Ca 2 -ATPase activities may play important roles in pathogenesis of hypertension in obese children.