| Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats |
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| 引用本文： | 张乐之,李英衢. Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats[J]. 中国人民解放军军医大学学报, 1991, 0(1) |
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| 作者姓名： | 张乐之 李英衢 |
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| 作者单位： | Department of Pharmacology Third Military Medical College，Chongqing 630038，Department of Pharmacology，Third Military Medical College，Chongqing 630038 |
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| 摘 要： | The increases of tracheal vascular permeability and malondialdehyde(MDA) content 1,2 and 3 h after introduction of hot air into the rat tracheaswere markedly inhibited by pethidine.The decreases of tracheal superoxidedismutase (SOD) activity 2 and 3h after hot air injury were elevated bypethidine.However,the inhibitory effect of pethidine on tracheal vascularpermeability was not antagonized by naloxone.This implies that opiate receptorsensitive to naloxone is not involved in the inhibitory effect of pethidine ontracheal vascular permeability.Pethidine could decrease MDA content and in-crease SOD activity.These antioxidative effects are beneficial to decreasingvascular permeability.
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Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats |
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| Zhang Lezhi Li Yingqu. Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats[J]. Journal of Medical Colleges of PLA(China), 1991, 0(1) |
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| Authors: | Zhang Lezhi Li Yingqu |
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| Affiliation: | Zhang Lezhi Li Yingqu Department of Pharmacology,Third Military Medical College,Chongqing 630038 |
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| Abstract: | The increases of tracheal vascular permeability and malondialdehyde (MDA) content 1,2 and 3 h after introduction of hot air into the rat tracheas were markedly inhibited by pethidine.The decreases of tracheal superoxide dismutase (SOD) activity 2 and 3h after hot air injury were elevated by pethidine.However,the inhibitory effect of pethidine on tracheal vascular permeability was not antagonized by naloxone.This implies that opiate receptor sensitive to naloxone is not involved in the inhibitory effect of pethidine on tracheal vascular permeability.Pethidine could decrease MDA content and in- crease SOD activity.These antioxidative effects are beneficial to decreasing vascular permeability. |
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| Keywords: | pethidine naloxone burns inhalation malondialdehyde superoxide dismutase capillary permeability |
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