A Life‐Threatening Flecainide Overdose Treated with Intravenous Fat Emulsion |
| |
| Authors: | HEATHER ELLSWORTH MD SAMUEL J STELLPFLUG MD JON B COLE MD JOSEPH A DOLAN MD CARSON R HARRIS MD |
| |
| Institution: | 1. Department of Emergency Medicine, Regions Hospital, , St. Paul, Minnesota;2. Hennepin Regional Poison Center, , Minneapolis, Minnesota;3. Department of Emergency Medicine, Methodist Hospital, , St. Louis Park, Minnesota |
| |
| Abstract: | Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life‐threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarbonate. We report a case of flecainide overdose associated with life‐threatening hemodynamic compromise successfully treated with intravenous fat emulsion (IFE) therapy. IFE should be considered as a novel adjunctive therapy in patients with life‐threatening toxicity following flecainide overdose. |
| |
| Keywords: | electrocardiogram hemodynamics pharmacology long QT |
|
|
