Indolent course of cutaneous gamma‐delta T‐cell lymphoma |
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Authors: | Dawnielle C. Endly Roger H. Weenig Margot S. Peters David S. Viswanatha Nneka I. Comfere |
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Affiliation: | 1. College of Osteopathic Medicine, Midwestern University, , Glendale, AZ, USA;2. Associated Skin Care Specialists, Dermatopathology Associates, , Fridley, MN, USA;3. Department of Dermatology, Mayo Clinic, , Rochester, MN, USA;4. Department of Laboratory Medicine and Pathology, Mayo Clinic, , Rochester, MN, USA |
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Abstract: | Cutaneous gamma‐delta T‐cell lymphoma (γδTCL) is a rare malignancy that typically displays an aggressive clinical course. We present an unusual case of a 57‐year‐old woman with a 3‐year history of lower extremity nodules. Histopathologic, immunophenotypic and molecular genetic studies revealed a clonal, predominantly pannicular gamma‐delta T‐cell infiltrate, leading to a diagnosis of cutaneous γδTCL. The clinical course was characterized by rapid improvement within months of starting systemic corticosteroids, with relapse in ulcerations but no new lesions more than 3 years after onset of disease. Our case and seven previously reported patients with indolent and relatively localized cutaneous γδTCL provide evidence that not all cases of this entity carry a poor prognosis. This indolent subset adds complexity to treatment of cutaneous γδTCL. |
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Keywords: | connective tissue disease panniculitis gamma‐delta T‐cell lymphoma panniculitic lymphoma |
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