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Leptin Modulates Allograft Survival by Favoring a Th2 and a Regulatory Immune Profile |
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| Authors: | P M M Moraes‐Vieira E J Bassi R A Larocca A Castoldi M Burghos A P Lepique F J Quintana R C Araujo A S Basso T B Strom N O S Câmara |
| Institution: | 1. Department of Immunology, Institute of Biomedical Sciences, University of S?o Paulo, S?o Paulo, SP, Brazil;2. Harvard Medical School, Beth Israel Medical Deaconess Center, Department of Medicine, Transplant Institute, Boston, MA;3. Harvard Medical School, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA;4. Department of Biophysics, Federal University of S?o Paulo, S?o Paulo, Brazil;5. Department of Microbiology, Immunology and Parasitology, Federal University of S?o Paulo, S?o Paulo, Brazil |
| Abstract: | Leptin, an adipose‐secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild‐type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection. |
| Keywords: | Alloimmunity leptin regulatory T cell tolerance |