Inhibition of naloxone-induced withdrawal in morphine dependent mice by l-trans-Δ9-tetrahydrocannabinol |
| |
| Authors: | Hemendra N Bhargava |
| |
| Institution: | Department of Pharmacognosy and Pharmacology, University of Illinois at the Medical Center, Chicago, Illinois 60612, U.S.A. |
| |
| Abstract: | The effects of various doses of l-trans-Δ9-tetrahydrocannabinol (Δ9-THC) on naloxone-induced withdrawal were studied in mice rendered dependent on morphine by the pellet implantation procedure. When administered i.p., 30 min prior to naloxone, Δ9-THC, inhibited the naloxone-induced withdrawal jumping response. Two other signs of morphine withdrawal (defecation and rearing behavior) were also suppressed by Δ9-THC. It is suggested that Δ9-THC or some of its derivatives may have potential use in narcotic detoxification. |
| |
| Keywords: | Morphine dependence Naloxone |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
