| CIK细胞的体外增殖及对Lewis肺癌小鼠抑瘤作用的实验研究 |
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| 引用本文： | 李淑艳,邢淑贤,杨凤坤,裴春颖,李呼伦,任欢,张伟光,李殿俊.CIK细胞的体外增殖及对Lewis肺癌小鼠抑瘤作用的实验研究[J].齐齐哈尔医学院学报,2004,25(1):1-2. |
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| 作者姓名： | 李淑艳 邢淑贤 杨凤坤 裴春颖 李呼伦 任欢 张伟光 李殿俊 |
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| 作者单位： | 1. 齐齐哈尔医学院生化教研室,161042
2. 哈尔滨医科大学免疫教研室 |
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| 摘 要： | 目的：观察CIK(cytokine induced killer)细胞及LAK(Lymphokine activated killer)细胞对Lewis肺癌小鼠的抑瘤作用。方法：建立Lewis肺癌小鼠动物模型，静脉输入CIK细胞做抗肿瘤治疗，同时设LAK对照，用同位素法检测各组小鼠T细胞增殖反应，同时用MTT法检测各组小鼠NK细胞毒活性。结果：CIK细胞对Lewis肺癌小鼠的抗肿瘤作用显著强于LAK细胞。结论：CIK细胞对Lewis肺癌小鼠有明显的抗肿瘤作用，并且优于LAK细胞。
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| 关 键 词： | CIK细胞 细胞增殖 Lewis肺癌 小鼠 肿瘤抑制 同位素法 MTT法 免疫活性细胞 |
| 修稿时间： | 2003年10月18 |
The Proliferation Profile in Vitro and Anti-Tumor Effects of CIK Cells in Vivo on the Mice Bearing Lewis Lung Cancer |
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| Li Shuyan,et al..The Proliferation Profile in Vitro and Anti-Tumor Effects of CIK Cells in Vivo on the Mice Bearing Lewis Lung Cancer[J].Journal of Qiqihar Medical College,2004,25(1):1-2. |
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| Authors: | Li Shuyan |
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| Abstract: | Objective To evaluate the anti-tumor activity of CIK ( cytokine induced killer ) cells on mice bearing Lewis lung cancer in vivo. Methods CIK cells were injected intravenously into the mice bearing Lewis lung cancer and compared with LAK controls in the same time. Results CIK cells had significantly anti-tumor effect which was much higher than that of LAK cells. Conclusions CIK cells had significantly anti-tumor effect on mice bearing Lewis lung cancer in vivo than that of LAK. |
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| Keywords: | CIK Lewis lung cancer Cell-mediated immunity |
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