<Emphasis Type="Italic">BRAF</Emphasis>, <Emphasis Type="Italic">KRAS</Emphasis> and <Emphasis Type="Italic">PIK3CA</Emphasis> mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis? |
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| Authors: | Sérgia Velho Cátia Moutinho Luís Cirnes Cristina Albuquerque Richard Hamelin Fernando Schmitt Fátima Carneiro Carla Oliveira Raquel Seruca |
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| Institution: | 1.Institute of Molecular Pathology and Immunology,University of Porto,Portugal;2.Centro de Investiga??o de Patobiologia Molecular-CIPM,Instituto Português de Oncologia Francisco Gentil,Lisboa,Portugal;3.Inserm, UMRS 762,Paris,France;4.Faculty of Medicine,University of Porto,Portugal;5.Hospital of S. Jo?o,Porto,Portugal |
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| Abstract: | Background
BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP), MLH1 methylation and microsatellite instability (MSI). We aimed at determine the frequency of KRAS, BRAF and PIK3CA mutations in the process of colorectal tumourigenesis using a series of colorectal polyps and carcinomas. In the series of
polyps CIMP, MLH1 methylation and MSI were also studied. |
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