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Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability |
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| Authors: | Se Hun Kang Keon Wook Kang Kyung-Hee Kim Bumi Kwon Seok-Ki Kim Ho-Young Lee Sun-Young Kong Eun Sook Lee Sang-Geun Jang Byong Chul Yoo |
| Affiliation: | (1) Research Institute and Hospital, National Cancer Center, Republic of Korea;(2) Department of Nuclear Medicine, School of Medicine, Seoul National University, Seoul, Korea |
| Abstract: | BackgroundElucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for the treatment of Her2-overexpressed metastatic breast cancer. |
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