Inhibitory effect of human blood granulocyte glycosaminoglycans on colony-forming activity of bone marrow fibroblasts |
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| Authors: | O. D. Golenko E. E. Batrak M. F. Kharchenko |
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| Affiliation: | (1) Department of Endogenous Modifiers of Carcinogenesis, Institute of Carcinogenesis, Oncology Research Center, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Inhibitory effect of glycosaminoglycans isolated from peripheral blood granulocytes of patients with chronic myeloleukemia and normal subjects on increment in colony-forming units of fibroblasts in monolayer cultures of rat bone marrow is determined by the degree of sulfation of their main component chondroitin-4-sulfate and by increased content of heparan sulfate. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 319–322, March, 1998 |
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| Keywords: | glycosaminoglycans increase in the number of colony-forming units of bone marrow fibroblasts |
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