The clinical significance of autoantibodies to soluble cellular antigens in systemic lupus erythematosus |
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Authors: | R Asero E Bertetti L Origgi P Riboldi C Zanussi |
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Affiliation: | Istituto di Clinica Medica I, Università degli Studi di Milano, Italia. |
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Abstract: | The relationships between autoantibodies to soluble cellular antigens and clinical features in systemic lupus erythematosus (SLE) were investigated in a large clinical-serological study. The absence of these precipitins in serum was associated with a low prevalence of vasculitis and membranous nephropathy (MGN). Other significant findings were the associations between nRNP antibody and Raynaud's phenomenon and MGN, SSB antibody and sicca complex, PCNA antibody and a young age at onset, and Bu antibody and an old age at onset. However, the most impressive findings were in DA1-positive patients which showed a unique prevalence of photosensitive skin lesions, lymphoadenopathy and hepatosplenomegaly. The present study confirms the usefulness of antibodies to soluble cellular antigens in the classification of patients with SLE. |
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