Complement-independent neutralising monoclonal antibody with differential reactivity for strains of human cytomegalovirus |
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| Authors: | C Baboonian K Blake J C Booth C N Wiblin |
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| Affiliation: | Department of Medical Microbiology, St. George's Hospital Medical School, University of London, England. |
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| Abstract: | A mouse monoclonal antibody with complement-independent neutralising activity against cytomegalovirus (CMV) and reactive with the 86 kilodalton (kDa) viral glycoprotein H is described. Neutralisation tests against a range of different strains of CMV showed significant crossreactivity, but clear differences were evident between the two prototype viruses AD169 and Davis, and particularly between AD169 and several low-passage recent clinical isolates; CMV present in urine was neutralised weakly if at all. |
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| Keywords: | glycoprotein H immunoprecipitation virus strain heterogeneity immunogold staining |
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