Clinical and experimental study of persical decoction for purgation with addition in the treatment of non-insulin dependent diabetes mellitus

This study conducted clinical observation of the treatment of non-insulin dependent diabetes mellitus (type I) with Semen Persical decoction for purgation with addition (SPDPA) in comparison with a control group treated with glyburide. The results of the clinical observations show the total effective rate of SPDPA on 106 cases was 79%, which was equivalent to levels in the control group, but SPDPA was more effective in relieving symptoms. The animal experimental study showed SPDPA could reduce fasting blood sugar in diabetic patients and rats. Its mechanism may be due to improved secretion of insulin, inhibited excretion by the endocrine cell, increased endocrine pellet inhibition of insular β-cells and improved composition of hepatic glycogen. In traditional Chinese medical theory, the mechanism of therapeutic action of SPDPA in diabetes mellitus is based on synergistic regulation benefiting the vital energy and nourishing Yin, the activation of blood circulation to dissipate blood stasis and the loosening of the bowel to relieve constipation.