鹅不食草化学成分研究

目的:对鹅不食草进行化学成分研究。方法:采用硅胶、反相硅胶、Sephadex LH-20凝胶柱色谱进行分离纯化,根据理化性质和光谱分析鉴定化合物结构。结果:从鹅不食草乙酸乙酯部位中分离得到4个化合物,从正丁醇部位中分离得到5个化合物,经鉴定分别为:7,4’-O-二甲基双氢山柰酚(1),莺尾甲苷A(2),5,8,4’-三羟基-7-甲氧基异黄酮(3),3-甲氧基槲皮素(4),3-O-咖啡酸-α-葡萄糖酯(5),3-O-咖啡酸-β-葡萄糖酯(6),槲皮素(7),表松脂醇(8),粗毛豚草素(9)。结论:化合物1～3,5～6,8～9为首次从该属植物中分离得到。

Chemical constituents of Centipeda minima

Objective: To study the chemical constituents from Centipeda minima.Method: The compounds were separated and purified by silica gel,reserved phase silica gel and Sephadex LH-20 gel column chromatography.Their structures were identified on the basis physicochemical property and spectral analysis.Result: Four chemical constituents were separated from ethyl acetate extracts and five chemical constituents were separated from n-butanol extracts of C.minima and identified as(2R,3R)-(+)-7,4′-di-O-methyldihydrokaempferol(1),iristectorin A(2),4′,5,8-trihydroxy-7-methoxyisoflavone(3),3-trimethoxyquercetin(4),3-O-caffeoyl-α-glueopyranose(5),3-O-caffeoyl-β-glucopyranose(6),quercetin(7),epipinoresinol(8) and hispidulin(9).Conclusion: Compounds 1-3,5-6,8 and 9 are separated from this genus for the first time.